| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 21/10/25 18.45 | FC Barcellona | Olympiacos Pireo | 6:1 |
| 21/10/25 18.45 | Kairat Almaty | Pafos FC | 0:0 |
| 21/10/25 21.00 | PSV Eindhoven | Napoli | 6:2 |
| 21/10/25 21.00 | FC Villarreal | Manchester City | 0:2 |
| 21/10/25 21.00 | FC Copenhagen | Borussia Dortmund | 2:4 |
| 21/10/25 21.00 | Royale Union Saint-Gilloise | Inter | 0:4 |
| 21/10/25 21.00 | FC Arsenal | Atletico Madrid | 4:0 |
| 21/10/25 21.00 | Newcastle United | Benfica Lisbona | 3:0 |
| 21/10/25 21.00 | Bayer 04 Leverkusen | Paris St. Germain | 2:7 |
| 22/10/25 18.45 | Galatasaray Istanbul | FK Bodö/Glimt | 3:1 |
| 22/10/25 18.45 | Athletic Bilbao | Qarabag | 3:1 |
| 22/10/25 21.00 | Real Madrid | Juventus | 1:0 |
| 22/10/25 21.00 | FC Bayern Monaco | Club Brügge | 4:0 |
| 22/10/25 21.00 | FC Chelsea | Ajax Amsterdam | 5:1 |
| 22/10/25 21.00 | Eintracht Francoforte | FC Liverpool | 1:5 |
| 22/10/25 21.00 | Atalanta | Slavia Praga | 0:0 |
| 22/10/25 21.00 | Sporting Lisbona | Olympique Marsiglia | 2:1 |
| 22/10/25 21.00 | AS Monaco | Tottenham Hotspur | 0:0 |