| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 09/12/25 16.30 | Kairat Almaty | Olympiacos Pireo | 0:1 |
| 09/12/25 18.45 | FC Bayern Monaco | Sporting Lisbona | 3:1 |
| 09/12/25 21.00 | AS Monaco | Galatasaray Istanbul | 1:0 |
| 09/12/25 21.00 | FC Barcellona | Eintracht Francoforte | 2:1 |
| 09/12/25 21.00 | PSV Eindhoven | Atletico Madrid | 2:3 |
| 09/12/25 21.00 | Atalanta | FC Chelsea | 2:1 |
| 09/12/25 21.00 | Tottenham Hotspur | Slavia Praga | 3:0 |
| 09/12/25 21.00 | Royale Union Saint-Gilloise | Olympique Marsiglia | 2:3 |
| 09/12/25 21.00 | Inter | FC Liverpool | 0:1 |
| 10/12/25 18.45 | FC Villarreal | FC Copenhagen | 2:3 |
| 10/12/25 18.45 | Qarabag | Ajax Amsterdam | 2:4 |
| 10/12/25 21.00 | Athletic Bilbao | Paris St. Germain | 0:0 |
| 10/12/25 21.00 | Bayer 04 Leverkusen | Newcastle United | 2:2 |
| 10/12/25 21.00 | Borussia Dortmund | FK Bodö/Glimt | 2:2 |
| 10/12/25 21.00 | Club Brügge | FC Arsenal | 0:3 |
| 10/12/25 21.00 | Juventus | Pafos FC | 2:0 |
| 10/12/25 21.00 | Real Madrid | Manchester City | 1:2 |
| 10/12/25 21.00 | Benfica Lisbona | Napoli | 2:0 |